Surface and tetrahedral mesh models are universally used in many areas such as graphics rendering, computational physics and medical imaging. However, high-quality mesh generation from complex 3D datasets has been a challenging task and there is no widely available tool for the research community. Over the past decade, we have developed one of the most popular open-source 3D mesh generation toolbox - iso2mesh. Since 2007, this toolbox has accrued over 18,000 worldwide downloads and attracted over 2,200 registered users. It plays a critical role in a wide variety of projects, ranging from high-energy physics research to computer visualization, attested by the nearly 300 paper citations.